DOWNLOAD Test Reports
DDRC SRL Healthcare Packages

DDRC SRL Clinical Test

Under Your Tests...Empower Your Health

Anti-lkm-1



Why Get Tested

To help diagnose autoimmune hepatitis and distinguish it from other causes of liver injury

When To Get Tested

When you have hepatitis that your healthcare practitioner suspects may be due to an autoimmune-related process

Sample Required

A blood sample drawn from a vein in your arm

Test Preparation Needed

None




Common Questions


The liver kidney microsome type 1 antibody anti-LKM-1 or CYP2D6 antibody test is primarily used along with a smooth muscle antibody SMA and an antinuclear antibodies ANA test to help diagnose autoimmune hepatitis and to differentiate between the two major types type 1 and type 2 These tests may be used to follow up abnormal liver test findings such as persistently increased alanine aminotransferase ALT aspartate aminotransferase AST or bilirubin Additional tests may be ordered such as immunoglobulins as these may be increased with autoimmune hepatitis and or hepatitis B and or hepatitis C to rule out viral hepatitis

The anti-LKM-1 test may be ordered when a healthcare practitioner is investigating an individual s liver disease and wants to distinguish between different causes of liver injury It may be ordered along with other testing such as an SMA and ANA test These tests are usually ordered when a person presents with signs and symptoms such as fatigue weakness and jaundice and has abnormal findings on routine liver tests Signs and symptoms associated with autoimmune hepatitis may also include Itching An enlarged liver Joint aches Abdominal discomfort Abnormal blood vessels in the skin spider angiomas Nausea or vomiting Dark urine Loss of appetite Pale or clay-colored stools Muscle pain myalgia In women lack of menstrual periods amenorrhea Skin rashes Fluid buildup edema Many of these signs and symptoms are not specific for autoimmune hepatitis they are also seen with other causes of liver injury and with other conditions

A high amount or titer of anti-LKM-1 indicates that it is likely that the person tested has type 2 autoimmune hepatitis but the result is not definitive A liver biopsy may be performed to evaluate liver tissue for damage and scarring to help confirm the diagnosis If the anti-LKM-1 test is negative but SMA and or ANA are positive then the person likely has type 1 autoimmune hepatitis If both are negative then the person s symptoms are likely due to a cause other than autoimmune hepatitis However the condition is not entirely ruled out Not all people with autoimmune hepatitis will produce anti-LKM-1 or SMA antibodies some people produce other autoantibodies that are rarely tested

Levels of anti-LKM-1 are not closely related to the severity of a person s symptoms or to that person s prognosis Levels may vary over time Those with type 2 autoimmune hepatitis may also have other autoimmune disorders such as diabetes or thyroiditis People with chronic hepatitis C may sometimes develop a different type of anti-LKM antibody sometimes referred to as anti-LKM3 This type of antibody is not detected with the usual anti-LKM-1 test methods and is not typically tested for The ANA test is often performed along with an SMA test It is a marker of an autoimmune process and is associated with several autoimmune disorders including type 1 autoimmune hepatitis

This is not usually necessary Most cases of hepatitis will be due to another identifiable cause However if the person with symptoms is a young girl without other risk factors and or the healthcare practitioner suspects an autoimmune process then anti-LKM-1 ANA and SMA testing may be performed

No Levels may vary over time but once the autoantibodies have developed they will be present throughout a person s life

Yes For instance autoimmune hepatitis can co-exist with a viral hepatitis such as hepatitis B or hepatitis C and can become worse with liver damage caused by alcohol abuse Since the treatment of hepatitis depends on the cause it is very important that your healthcare practitioner understand the underlying cause s of your condition

The course and severity of autoimmune hepatitis is hard to predict It may be acute or chronic Some people will have no or few symptoms for many years and are diagnosed when routine liver tests are abnormal Those with type 2 autoimmune hepatitis often have a more severe case but it is usually manageable with proper treatment Appropriate treatment is important to limit liver damage For more information consult with your healthcare provider and see the related links

This antibody was originally detected using tissue from the liver and kidney hence the name anti-LKM-1 However the specific protein in those tissues that the antibody targets the major antigen has since been identified as cytochrome P450 2D6 CYP2D6 This protein is a major enzyme that metabolizes about 25 of drugs as well as toxic substances It is primarily found in cells of the liver and kidney mainly within structures called microsomes