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Anti-saccharomyces-cerevisiae-antibodies-asca



Why Get Tested

To help distinguish between Crohn disease CD and ulcerative colitis UC the two most common types of inflammatory bowel disease IBD as an adjunct to other IBD testing

When To Get Tested

When you have symptoms such as persistent or intermittent diarrhea and abdominal pain that your healthcare practitioner suspects may be due to an IBD when your healthcare practitioner wants to distinguish between CD and UC

Sample Required

A blood sample drawn from a vein in your arm

Test Preparation Needed

None




Common Questions


The test for anti-Saccharomyces cerevisiae antibodies ASCA is used to help distinguish between Crohn disease CD and ulcerative colitis UC the two most common types of inflammatory bowel disease IBD Testing usually includes detecting two different classes of ASCA in the blood IgG and IgA ASCA are immune proteins that are frequently present in people who have IBD The association between the presence of ASCA and their involvement in the disease process however is not understood at this time IBDs are primarily diagnosed through non-laboratory evaluations such as a biopsy of the intestine In some cases however it can be difficult to distinguish between CD and UC An ASCA test is often ordered along with a test for perinuclear anti-neutrophil cytoplasmic antibody pANCA to help determine which type of IBD a person has The presence of ASCA is more common in CD while pANCA is more common in UC Anti-CBir1 anti-flagellin antibody and anti-Omp C anti-outer membrane protein antibody are indicative of CD and may also be used in combination with ASCA testing Since the symptoms associated with IBD may be seen with a number of conditions other tests are frequently performed prior to or along with ASCA testing to rule out other causes for the symptoms For more on this see the article on Inflammatory Bowel Disease

ASCA testing is primarily ordered when a person has signs and symptoms that suggest IBD and a healthcare practitioner is attempting to distinguish between CD and UC It may be ordered along with pANCA and other antibody testing Signs and symptoms of an IBD may include Abdominal pain and cramps Diarrhea Rectal bleeding Fever Fatigue In some people joint skin bone and organ-related symptoms Children may also have delayed development and growth retardation

A positive ASCA result is not diagnostic of CD UC or of an IBD but it does make it more likely that a person with symptoms has an IBD Results of ASCA testing are often interpreted in conjunction with the results of pANCA testing If ASCA is positive and pANCA is negative then it is likely that the person has CD If ASCA is negative and pANCA is positive then it is likely that the person has UC A negative result for ASCA and pANCA does necessarily rule out IBD A person who is negative may still have CD UC or another IBD The presence of multiple antibodies ASCA anti-CBir1 anti-Omp C may indicate the likelihood of a more aggressive disease but negative results do not rule out aggressive disease

There are many other antibody biomarkers that are associated with IBD The amount of ASCA and or pANCA present does not correlate with the severity of a person s symptoms or condition and it cannot be used to monitor response to treatment

Testing is usually only performed once to help distinguish between CD and UC It is typical to order tests for the two classes of antibody ASCA IgG and ASCA IgA at the same time However if only one of the types was initially ordered then the other type or more likely both may be ordered at a later date

No it is not necessary in most cases as these symptoms are common and are most frequently due to something other than IBD Most people will never need to have ASCA testing performed

The level of antibody may vary over time but once a person s body has produced ASCA it will continue to be present

In general no It is not offered by every hospital laboratory It may be necessary to send your blood sample to a reference laboratory for testing