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Apo-i



Why Get Tested

To determine whether or not you have an adequate level of apo A-I especially if you have a low level of high-density lipoprotein HDL-C and to help determine your risk of developing cardiovascular disease CVD

When To Get Tested

When you have high cholesterol and triglycerides hyperlipidemia and or a family history of CVD when your health care provider is trying to assess your risk of developing heart disease when monitoring the effectiveness of lipid treatment and or lifestyle changes

Sample Required

A blood sample drawn from a vein in your arm blood from the prick of a baby s heel or finger

Test Preparation Needed

None however this test is often ordered at the same time as other tests that require fasting so you may be instructed to fast for 12 hours prior to having this test




Common Questions


Apolipoprotein A-I apo A-I may be ordered along with other lipid tests as part of a profile to help determine a person s risk of developing cardiovascular disease CVD It may be used as an alternative to a high-density lipoprotein HDL test but it is not generally considered better or more informative than HDL and is not ordered routinely Apo A-I is a protein that has a specific role in the metabolism of lipids and is the main protein component in HDL the good cholesterol HDL removes excess cholesterol from cells and takes it to the liver for recycling or disposal Levels of apo A-I tend to rise and fall with HDL levels and deficiencies in apo A-I correlate with an increased risk of developing CVD An apo A-I test may sometimes be ordered to Help diagnose inherited or acquired conditions that cause apo A-I deficiencies Help evaluate people who have a personal or family history of heart disease and or high cholesterol and triglycerides Monitor the effectiveness of lifestyle changes and lipid treatments An apo A-I may be ordered along with an apolipoprotein B apo B test to determine an apo B apo A-I ratio This ratio is sometimes used as an alternative to a total cholesterol HDL ratio sometimes reported as part of a lipid profile to evaluate risk for developing CVD

Apo A-I may be measured when someone has a personal or family history of abnormal lipid levels and or premature CVD It may be ordered when a health practitioner is trying to determine the cause of a person s high cholesterol and or suspects it may be due to a disorder that is causing a deficiency in apo A-I Apo A-I may be ordered along with apo B when a health practitioner wants to check an apo B apo A-I ratio as a CVD risk indicator to evaluate the bad to good cholesterol Apo A-I may be ordered along with other tests when someone has undergone lipid-lowering treatment or lifestyle changes such as decreased dietary fat and increased regular exercise to monitor the effectiveness of the changes

Low levels of apo A-I are associated with low levels of HDL and impaired clearance of excess cholesterol from the body Low levels of apo A-I along with high concentrations of apo B are associated with an increased risk of cardiovascular disease There are some genetic disorders that lead to deficiencies in apo A-I and therefore to low levels of HDL People with these disorders tend to have abnormal lipid levels including high levels of low-density lipoprotein LDL the bad cholesterol Frequently they have accelerated rates of atherosclerosis These genetic disorders are primary causes of low apo A-I For more on some of these disorders see the Related Pages tab Changes in levels of apo A-I may also be associated with other factors Some of the conditions that contribute to decreases or increases in apo A-I are listed below Apo A-I may decrease with Chronic kidney disease Use of drugs such as androgens beta blockers diuretics and progestins synthetic progesterone Smoking Uncontrolled diabetes Obesity Apo A-I may increase with Use of drugs such as carbamazepine estrogens ethanol lovastatin niacin oral contraceptives phenobarbital pravastatin and simvastatin Physical exercise Pregnancy Weight reduction Use of statins

The concentration of apo A-I reflects the amount of HDL in the serum Since women tend to have higher HDL they also have higher levels of apo A-I The apo A-I test is not routinely ordered Health practitioners still have to determine the best uses for the apo A-I and other tests for emerging cardiac risk markers such as apo B hs-CRP and Lp a They offer additional information in specific situations but are not meant to replace the lipid tests already routinely available

Regular exercise is one of the best ways to raise HDL and apo A-I By decreasing the saturated fat in your diet maintaining a healthy weight and exercising you can help decrease your risk of developing heart disease

No the apo A-I test requires specialized equipment and is not offered by every laboratory Your blood may need to be sent to a reference laboratory for testing